Buprenorphine (Subutex, Suboxone, Zubsolv, Temgesic, Buprenex, Norspan, Butrans)
Opiates Immunoassay
Opiates - Negative
Opiates - Positive
GC/MS or LC/MS Buprenorphine
Buprenorphine / Nor buprenorphine
Buprenorphine / Nor buprenorphine - None detected
Tramadol; other opioids including (Codeine, Heroin, Morphine)
1 to 10 days after use
Synthetic Opioid
Codeine (Tylenol #3 or #4)
Opiates Immunoassay
Opiates - Positive
Opiates - Negative
GC/MS or LC/MS Opiates
Codeine, possibly Morphine
Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, or 6-acetyl morphine (Heroin metabolite)
Poppy seeds; dextromethorophan; diphenhydramine; fluoroquinolones; quinine, rifampin
2 to 4 days after use
Opiate
Fentanyl (Abstral, Actiq, Duragesic, Fentora, Ionsys, Lazanda, Onsolis, Subsys)
Not detected by screening test. Use confirmatory test.
Not detected by screening test. Use confirmatory test.
Opiates - Positive by Immunoassay
GC/MS or LC/MS Fentanyl
Mass Spectrometry
Fentanyl and Norfentanyl
Highly Unlikely
1 to 2 days after use
Synthetic Opioid
Hydrocodone (Histinex HC, Hycodan, Hycotuss, Tussionex, Vicodin, Lorcet, Lortab, Norco, Rezira, Vicoprofen, Vituz, Zohydro ER, Zolvit, Zutripro, Zydone)
Opiates by Immunoassay
Opiates - Positive
Opiates - Negative
GC/MS or LC/MS Opiates
Hydrocodone, possibly Hydromorphone
Codeine, Morphine, Oxycodone, Oxymorphone, or 6-acetyl morphine (Heroin metabolite)
Poppy seeds ; dextromethorophan; diphenhydramine; fluoroquinolones; quinine, rifampin
1 to 4 days after use
Semi-Synthetic Opioid
Hydromorphone (Exalgo, Hydromorphone HP, Dilaudid, Palladone)
Opiates by Immunoassay
Opiates - Positive
Opiates - Negative
GC/MS or LC/MS Opiates
Hydromorphone
Codeine, Morphine, Hydrocodone, Oxycodone, Oxymorphone, 6-acetyl morphine (Heroin metabolite)
Poppy seeds ; dextromethorophan; diphenhydramine; fluoroquinolones; quinine, rifampin
1 to 4 days after use
Semi-Synthetic Opioid
Meperidine (Demerol, Mepergan)
Not detected by screening test. Use confirmatory test.
Not detected by screening test. Use confirmatory test.
Opiates - Positive by Immnoassay
GC/MS or LC/MS Meperidine
Normeperidine, possibly Meperidine
Codeine, Morphine, Hydrocodone, Oxycodone, Oxymorphone, 6-acetyl morphine (Heroin metabolite)
Diphenhydramine; doxylamine; clomipramine; chlorpromazine; quitiapine; thioridazine; tramadol; verapamil
Meperidine: <1 day; Normeperidine: upto 2 days
Synthetic Opioid
Methadone (Dolophine, Methadose®)
Methadone Immunoassay
Methadone - Positive
Opiates - Positive
GC/MS or LC/MS Methadone
Methadone and EDDP
Methadone only
clomipramine; chlorpromazine; Diphenhydramine; doxylamine; ibuprofen; quitiapine; thioridazine; verapamil
Up to 10 days; Detection times of methadone in urine can be variable: patients on lower doses (<40mg) of methadone may screen Negative by Immunoassay.
Synthetic Opioid
Morphine (Apokyn, Avinza®, DepoDur, Duramorh, Embeda, Kadian®, MSContin®, MSIR®, Oramorph SR®, Paregoric, Roxanol®)
Opiates Immunoassay
Opiates - Positive
Opiates - Negative
GC/MS or LC/MS Opiates
Morphine, possibly Hydromorphone if on high dose or chronic Morphine
Codeine, Hydrocodone, Oxycodone, Oxymorphone, 6-acetyl morphine (Heroin metabolite)
Diphenhydramine; doxylamine; clomipramine; chlorpromazine; ibuprofen; quitiapine; thioridazine; tramadol; verapamil
1 to 4 days after use
Opiate
Oxycodone (Combunox, Endocet, Oxecta, OxylR®, Percocet, Percodan, Roxicodone, Roxicet, Tylox®, Xartemis XR)
Oxycodone Immunoassay
Oxycodone - Positive; Opiates - Negative, dose <100 mg/day; Opiates - Positive by Immunoassay, dose >100 mg/day
Oxycodone - Negative by Immunoassay; Opiates - Negative, dose >100 mg/day; Opiates - Positive by Immunoassay, dose <100 mg/day
GC/MS or LC/MS Opiates
Oxycodone, Oxymorphone
Codeine, Morphine, Hydrocodone, Hydromorphone, 6-acetyl morphine (Heroin metabolite)
Poppy seeds ; dextromethorophan; diphenhydramine; fluoroquinolones; quinine, rifampin
1 to 4 days after use
Semi-Synthetic Opioid
Oxycodone®ER (Oxycontin)
Oxycodone Immunoassay
Oxycodone - Positive; Opiates - Positive, dose > 100 mg/day
Oxycodone - Negative
GC/MS or LC/MS Opiates
Oxycodone and Oxymorphone
Codeine, Morphine, Hydrocodone, Hydromorphone, or 6-acetyl morphine (Heroin metabolite)
Poppy seeds ; dextromethorophan; diphenhydramine; fluoroquinolones; quinine, rifampin
1 to 4 days after use
Semi-Synthetic Opioid
Oxymorphone (Opana®, Opana ER®, Numorphan)
Oxycodone Immunoassay
Oxycodone - Positive
Opiates - Positive by Immunoassay
GC/MS or LC/MS Opiates
Oxymorphone
Codeine, Morphine, Hydrocodone, Hydromorphone, Oxycodone, or 6-acetyl morphine (Heroin metabolite)
Naloxone, see list for opiates
1 to 4 days after use
Semi-Synthetic Opioid
Propoxyphene (Darvon®, Darvocet®)
Propoxyphene Immunoassay
Propoxyphene - Positive
Opiates - Positive by Immunoassay
GC/MS or LC/MS Propoxyphene
Propoxyphene / Norpropoxyphene
Codeine, Morphine, Hydrocodone, Oxycodone, Oxymorphone, 6-acetyl morphine (Heroin metabolite)
Poppy Seeds; Codeine
1 to 5 days after use
Synthetic Opioid
Tramadol (Ultram®, Ultracet®)
Not detected by screening test. Use confirmatory test.
Not detected by screening test. Use confirmatory test.
Opiates - Positive by Immunoassay
GC/MS or LC/MS Tramadol
Tramadol and metabolites
Codeine, Morphine, Hydrocodone, Oxycodone, Oxymorphone, 6-acetyl morphine (Heroin metabolite)
Dextromethorphan
1 to 24 hrs after use
Semi-Synthetic Opioid
